Take this medication by mouth with or without food stuff as directed by your physician, generally each individual four to six several hours as required. This medication may be taken with foodstuff if tummy upset occurs. Consume plenty of fluids any time you use this medication Except otherwise directed by your doctor.
Don't use a family teaspoon to measure your medication. You might accidently choose too much. Tend not to overfill the measuring gadget. Rinse your measuring system with drinking water following Each and every use.
The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complicated, requiring very careful thing to consider of the effects over the dad or mum drug, codeine, as well as active metabolite, morphine.
Steer clear of the usage of Promethazine with Codeine Oral Option in people with head harm, intracranial lesions, or a pre-existing rise in intracranial pressure. In individuals who could be prone to the intracranial outcomes of CO 2 retention (eg., People with proof of amplified intracranial force or Mind tumors), Promethazine with Codeine Oral Resolution may perhaps lower respiratory travel, and also the resultant CO two retention can even more maximize intracranial pressure.
Cure of overdosage is pushed by the general clinical presentation, and consists of discontinuation of Promethazine with Codeine Oral Answer jointly with institution of correct therapy. Give Key focus on the reestablishment of satisfactory respiratory Trade as a result of provision of a patent and protected airway as well as establishment of assisted or controlled air flow.
Always consult your Health care service provider to be sure the data displayed on this website page applies to your personal circumstances.
This solution may have inactive components, which often can induce allergic reactions or other complications. Speak to your pharmacist For additional details.
The specific mechanism of action of codeine and various opiates just isn't acknowledged; more info even so, codeine is considered to act centrally on the cough Middle. In extreme doses, codeine will depress respiration.
Significant, lifestyle-threatening, or deadly respiratory despair has been claimed with using opioids, which include codeine, among the active elements in Promethazine with Codeine Oral Solution. Codeine generates dose-related respiratory melancholy by directly acting around the brain stem respiratory Middle that controls respiratory rhythm and may produce irregular and periodic respiration. Codeine is subject matter to variability in metabolism centered upon CYP2D6 genotype, which may lead to a heightened publicity to the Energetic metabolite morphine [see WARNINGS AND Safeguards (five.3)]. Promethazine exerts a depressant impact on the respiratory Heart which is impartial of and additive to that of other respiratory depressants, such as codeine [see WARNINGS AND Safety measures (five.
Promethazine VC with Codeine can gradual or quit your respiratory, and Demise might occur. Somebody caring for it is best to seek out crisis health care awareness When you've got sluggish breathing with long pauses, blue coloured lips, or In case you are difficult to wake up.
Prior to having this medication, notify your medical professional or pharmacist Should you be allergic to any of its ingredients; or to opioid agony relievers (which include morphine); or In case you have some other allergic reactions.
Place the mixture within a container for instance a sealed plastic bag and throw it absent from the home trash. You can even follow your state or community pointers on how to properly toss away PROMETHAZINE WITH CODEINE ORAL SOLUTION.
Keep at room temperature from light-weight and moisture. Never retailer in the lavatory. Don't freeze. Retain all medications faraway from youngsters and Animals.
The danger for significant respiration troubles is increased when you start this medication, or if you are taking the wrong dose or just take additional of the medication than prescribed. Using this medication with alcohol or other medications that can cause drowsiness or breathing difficulties may well trigger quite critical Unwanted side effects, which includes Loss of life. Also, other drugs can have an effect on the removal of this solution out of your entire body, which may impact how it works.